MicroRNAs: Emerging Novel Targets of Cancer Therapies

MicroRNAs: Emerging Novel Targets of Cancer Therapies

1Department of Physiology, Center for Integrative Toxicology, 4171 Biomedical Physical Sciences, Michigan State University, East Lansing, MI 48824, USA 2Institute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Disease, Guangzhou Medical University 195, Dongfeng Road West, Guangzhou, Guangdong 510182, China 3Department of Oncologic Sciences, Mitchell Cancer Institute, Universit...

AB010. Molecular pathophysiology of priapism: emerging targets and novel therapies

60 vs. 61 to 90 degrees) and randomized to CCh or placebo 2:1 in favour of the former. Post hoc meta-analysis of IMPRESS I and II data revealed that men treated with CCh showed a mean 34% improvement in penile curvature, representing a mean ±SD −17.0±14.8 degree change per subject, compared with a mean 18.2% improvement in placebo treated men, representing a mean −9.3±13.6 degree change per sub...

Emerging epigenetic targets and therapies in cancer medicine.

UNLABELLED Abnormalities in the epigenetic regulation of chromatin structure and function can lead to aberrant gene expression and cancer development. Consequently, epigenetic therapies aim to restore normal chromatin modification patterns through the inhibition of various components of the epigenetic machinery. Histone deacetylase and DNA methyltransferase inhibitors represent the first putati...

micrornas: promising potential targets for cancer treatment

Insights into role of microRNAs in cardiac development, cardiac diseases, and developing novel therapies

Objective(s): MicroRNAs (miRNAs) are a subfamily of small noncoding RNAs that play a variety of roles in regulating gene expression in nearly all organisms. They affect different biological pathways by post-transcriptionally regulating mRNAs. Aside from miRNAs’  role in maintaining cellular homeostasis, their perturbation is related to several pathologic states and dis...